A condition that affects the blood’s ability to clot.
For ones blood to clot one needs blood cells calls platelets, the platelets have a sticky surface which join with other platelets to allow blood to clot.
On the surface of the platelet there are proteins which help to for a ‘web’ called fibrin this helps the platelets to stick together.
To form Fibrin one needs a series of reactions and cells/proteins called clotting factors, hemophilia is when one has a lack of certain clotting factors hence it takes longer to form fibrin and hence for the body to clot.
There are different types of hemophilia depending to blood clotting factors affected:
However, females may have clinical bleeding if any of the following three conditions is present:
Extreme lyonization (i.e. inactivation of the normal factor VIII allele in one of the X chromosomes)
Homozygosity for the haemophilia gene (i.e. father with haemophilia and mother who is a carrier, two independent mutations, or some combination of inheritance and new mutations)
Turner syndrome (XO) associated with the affected haemophilia gene
Medscape
Diagnosis Test
Activated partial thromboplastin time (aPTT) test – allows for an immediate screening of the intrinsic pathway (factors VIII [FVIII], IX, XI, and XII) with rapid results.
Cause
Family history
Mutated gene (a gene contains our DNA sequence and contains information of us in our cells), the DNA sequence has been altered and affects the proteins in their cells to perform their functions.
Acquired haemophilia (condition caused from other diseases/condition /medication) i.e.
Pain, numbness, burning and tingling (pins and needles) sensation in one’s hands and fingers (thumb and/or index finger and/or middle finger and/or ring finger and/or small finger)?
Pain and/or numbness and/or tingling sensation in one or both legs and/or foot area and/or leg aching which comes and goes?
Inflamed (hot, red and swollen) joints, tenderness and warmth to the touch?
Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice
Detailed Information
Please copy and paste any key words from the title: Haemophilia in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).
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