Lymphogranuloma venereum (LGV) - Medtick

Lymphogranuloma venereum (LGV)

What is it?

Lymphogranuloma venereum (LGV) is an uncommon sexually transmitted disease mainly causing swelling and infection to the neck (below jaw), armpits and/or groin and anus regions.

  • The disease goes through 3 distinct stages as it develops.
  • The first 2 stages of lymphogranuloma venereum may be minor, and you might not even be aware of any symptoms until you reach stage 3, called the genito anorectal syndrome.

First stage:

  • If have sexual activity, 3–30 day (incubation period) later first symptoms (lesions) appear.

Second stage ((inguinal):

  • 2–6 weeks after the first lesion appears and consists of painful swelling of the groin or other lymph nodes.

Third stage:

This is called genito anorectal syndrome and females normally their symptoms at this stage, at this point one will have severe anus/abdominal infections, boil infections  and deep skin infections.


  • It is commonly seen in tropical and subtropical countries though it can affect anyone.
  • Anyone who has unprotected sex is at risk for lymphogranuloma venereum.
Persons who have had sexual contact with anyone who has lymphogranuloma venereum within 60 days before the affected person had symptoms should be examined and tested.

Cause

  • Bacteria: Chlamydia trachomatis (Serovars L1, L2, and L3)
  • Spread through having unprotected vaginal, oral and/or anal sex.

Symptoms

First stage:

  • Small painless bump or pus-filled lesion forms (on the penis, scrotum, vulva, or in the vagina) that may wear away to form an open sore (ulcer)?
  • Lesion often has no symptoms and heals without scarring within about a week?

Second stage (male notice symptoms more earlier than females due to swelling in groin is not easily seen in females):

  • High temperature greater than 38°C (100°F) or over and/or chills and sweats longer than 72 hours?
  • General discomfort (muscle weakness), uneasiness or ill feeling (malaise) and/or fatigue (tiredness)
  • Painful and swollen lymph nodes in neck (below jaw), armpits and/or groin?
  • Develop a “groove sign” caused by pressure from the tight ligament separating the groin lymph nodes?
  • Nodes join together to form “buboes,” which may split open and drain, or they may become hard and then slowly heal on their own?
  • Abdominal pain and/or are constant violently vomiting or vomiting longer than two days (one day if a child)?
  • Infection is in the anus, one may have blood or mucus coming out from the opening to the large intestine (rectum)?

Third stage (Genito anorectal syndrome):

  • Infected in the anus have rectal infection (proctocolitis) including mucus and bleeding ?
  • Pain in anus and when going to the toilet to excrete faeces?
  • Deep boils (abscesses) and scarring?
  • Swollen genitals?
  • Abdominal pain and/or are constant violently vomiting or vomiting longer than two days (one day if a child)?

Complications /Information to beware of/General tips:

This condition can lead to:

  • Skin ulcers (open skin wound)
  • Skin infection
  • Suppurative lymphadenitis – tissue infections caused by bacteria that appear like large swellings lumps and boils [as one can transfer the Soft chancre (ulcer) leak and pus to other parts of body and to others during sexual intercourse].
    • Symptoms include lymph nodes which are:
      • Nodes that increase in size.
      • Nodes that are painful to touch.
      • Nodes that are soft or matted together.
      • Redness or red streaking of the skin over nodes.
      • Nodes that are filled with pus (an abscess).
      • Fluid that drains from the nodes to the skin.
  • Genital elephantiasis:
    • Males: massive enlargement of genitals, not penile area but more of the scrotum area in males
    • Female: swelling of surrounding vaginal area
  • If anus affected:

This condition can exist with:

  • Chlamydia
  • H.I.V (a H.I.V test should be preformed if symptoms are ongoing)

This condition may show similar symptoms to:

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Lymphogranuloma venereum (LGV) in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

  • NHS

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  • Medscape

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  • Pharmaceutical Journal

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  • WebMD

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  • Cleveland Clinic

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  • Drugs.com

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  • National Organisation of Rare Diseases

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  • Verywell Health

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  • Fit for Travel

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  • DR Axe

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