What is it?
A gap at the roof of the mouth , it is there because parts of the baby’s face did not join together properly during development in the womb.
- It is present from birth.
www.nhs.uk
- Some person may also have cleft lip with this condition.
Cause
- Family history
- Aarskog syndrome
- Acrocallosal syndrome
- Acrocephalopolysyndactyly disorders (Apert syndrome, Chotzen syndrome, Carpenter syndrome, Jackson-Weiss syndrome, Pfeiffer syndrome)
- Ankyloblepharon-ectodermal dysplasia-cleft lip/palate (AEC) syndrome
- Arthrogryposis
- ASXL3-related disorder (Bainbridge-Ropers syndrome)
- Bohring-Opitz syndrome
- Branchio-oculo-facial syndrome
- Branchiootorenal syndrome (pits or ear tags in front of the outer ear)
- Campomelic syndrome
- Cat eye syndrome
- Catel-Manzke syndrome
- Caudal regression syndrome
- Cerebrocostomandibular syndrome
- CHARGE syndrome
- Chromosome 10, distal trisomy 10q and other chromosome deletion disorders
- Cleidocranial dysplasia
- Cornelia de Lange syndrome
- Cross Syndrome (inflamed gums, light hair and skin)
- Craniofrontonasal dysplasia
- Cri du chat syndrome (cry that resembles the mewing of a cat)
- DiGeorge syndrome
- Deoxyhypusine synthase
- Diastrophic dysplasia (disastrophic dwarfism)
- Dubowitz syndrome (narrow or triangle-shaped face with a high or sloping forehead, eczema, vision problems)
- Ellis-Van Creveld syndrome
- Femoral facial syndrome
- Filippi syndrome
- Fragile X syndrome
- Freeman-Sheldon syndrome (whistling face syndrome)
- Frontofacionasal dysplasia
- Frontonasal dysplasia
- Fryns syndrome
- Goltz syndrome
- Gordon syndrome
- Gorlin-Chaudhry-Moss syndrome
- Hallermann-Streiff syndrome
- Hanhart syndrome
- Hereditary neuralgic amyotrophy (recurrent episodes of severe pain in the shoulder and arm)
- Holoprosencephaly
- Hypomelanosis of Ito (develop areas that lack skin colour)
- IRF6-related disorders
- Jackson-Weiss syndrome
- Jansen type metaphyseal chondrodysplasia
- Johanson-Blizzard syndrome
- Kabuki syndrome
- KAT6B-related disorders
- Klippel-Feil syndrome
- Kniest dysplasia
- Lenz microphthalmia syndrome
- Leri-Weill dyschondrosteosis
- Loeys-Dietz syndrome
- Marden-Walker syndrome
- Meckel-Gruber syndrome
- MEF2C deficiency
- Megalocornea-intellectual disability syndrome
- Meier-Gorlin syndrome
- Miller syndrome
- Moebius syndrome (eyes do not move from side-to-side, facial paralysis or weakness affecting at least one but usually both sides of the face)
- Mosaic trisomy 9
- Muenke syndrome
- Nemaline myopathy
- Neu-Laxova syndrome
- Oculo-auriculo-vertebral spectrum [abnormalities tend to involve the cheekbones, jaw, mouth, ears, eyes, and/or bones of the spinal column (vertebrae)] – Goldenhar variant
- Oculo-dento-digital dysplasia
- Orocraniodigital syndrome
- Opitz trigonocephaly syndrome
- Homozygous OSMED
- Pallister-Killian mosaic syndrome
- Pallister W syndrome
- Penta X syndrome
- Pentalogy of Cantrell
- Pterygium syndrome Multiple
- Refsum Disease (Zellweger spectrum disorders)
- Rubinstein-Taybi syndrome
- Russell-Silver syndrome
- Seckel syndrome
- Simpson-Golabi-Behmel syndrome
- Smith Lemli Opitz syndrome
- Sotos syndrome
- Shprintzen Goldberg syndrome
- Spondyloepiphyseal dysplasia congenita
- Stickler syndrome
- Thrombocytopenia-absent radius syndrome
- Treacher Collins syndrome
- Trisomy 13 Syndrome
- Turner syndrome
- Weill Marchesani syndrome [short stature, broad head (brachycephaly) and joint stiffness]
- Wiedemann-Steiner syndrome
- Wildervanck syndrome
- Abnormal union or fusion of two or more bones of the spinal column (vertebrae) within the neck (Klippel-Feil syndrome)
- Impairment or absence of certain eye (ocular) movements (Duane syndrome)
- Hearing impairment
- Wolf-Hirschhorn syndrome
- X-linked Opitz G/BBB syndrome
Complications /Information to beware of/General tips:
This condition can lead to:
- Difficulty feeding – a baby with a cleft lip and palate may be unable to breastfeed or feed from a normal bottle because they cannot form a good seal with their mouth
- Hearing problems :
- Some babies with a cleft palate are more vulnerable to ear infections and a build-up of fluid in their ears (glue ear), which may affect their hearing
- Dental problems – a cleft lip and palate can mean a child’s teeth do not develop correctly and they may be at a higher risk of tooth decay.
- Speech problems – if a cleft palate is not repaired, it can lead to speech problems such as unclear or nasal-sounding speech when a child is older
www.nhs.uk
Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice
Detailed Information
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