Tetanus - Medtick

Tetanus

What is it?

A short-lived but severe bacterial infection. The bacteria once in the body grows and blocks nerve signals sent from the brain and spinal cord to ones muscles.

  • One normally develops the symptoms after one week after exposure (range can be from three to twenty-one days) and it cannot be passed from person to person.
  • The effects can be long lasting 5- 6 weeks as the body needs time to recover and regrow cells (anterior horn cells) to promote normal muscle contraction.
One should get a tetanus jab/shot with 48 hours of injury, if required (especially if one has not had a tetanus jab/shot for more than 10 years)

Countries affected are:

Caribbean

  • Anguilla
  • Antigua and Barbuda
  • Aruba
  • Bahamas
  • Barbados
  • Bonaire
  • British Virgin Islands
  • Cayman Islands
  • Cuba
  • Curaçao
  • Dominica
  • Dominican Republic
  • Grenada
  • Guadeloupe
  • Haiti
  • Jamaica
  • Martinique
  • Montserrat
  • Puerto Rico
  • Saba
  • Saint Barthelemy (French Territorial Collectivity)
  • Saint Kitts and Nevis
  • Saint Lucia
  • Saint Martin (French Territorial Collectivity)
  • Sint Eustatius
  • Sint Maarten
  • Trinidad and Tobago
  • Turks and Caicos
  • US Virgin Islands

North America

  • Bermuda
  • Canada
  • Greenland
  • Mexico
  • Saint Pierre and Miquelon
  • United States of America (Alaska, Hawaii, Oahu, Maui)

Central America

  • Belize
  • Costa Rica
  • El Salvador
  • Guatemala
  • Honduras
  • Nicaragua
  • Panama

South America

  • Antarctica (Polar Region)
  • Argentina
  • Bolivia
  • Brazil
  • Chile (Easter Island)
  • Colombia
  • Ecuador (Galapagos Islands)
  • Falkland Islands
  • French Guiana
  • Guyana
  • Paraguay
  • Peru
  • Suriname
  • Uruguay
  • Venezuela (Margarita Island)

Europe & Russia

  • Albania
  • Andorra
  • Armenia
  • Austria
  • Azerbaijan
  • Belarus
  • Belgium
  • Bosnia Herzegovina
  • Bulgaria
  • Croatia
  • Cyprus
  • Czech Republic
  • Denmark
  • Estonia
  • Faroe Islands
  • Finland
  • France (Corsica)
  • Georgia
  • Germany
  • Gibraltar
  • Greece (Corfu, Crete, Rhodes)
  • Hungary
  • Iceland
  • Ireland
  • Italy (Sardinia, Sicily)
  • Kosovo
  • Latvia
  • Liechtenstein
  • Lithuania
  • Luxembourg
  • Malta
  • Monaco
  • Montenegro
  • Netherlands
  • Norway (Svalbard)
  • Poland
  • Portugal (Azores, Madeira)
  • Republic of Moldova
  • Republic of North Macedonia
  • Romania
  • Russian Federation
  • San Marino
  • Serbia
  • Slovakia
  • Slovenia
  • Spain (Spain Majorca, Minorca, Balearic Islands, Ibiza, Formentera, Canary Islands, Gran Canaria, Tenerife, Lanzarote, Fuerteventura)
  • Sweden
  • Switzerland
  • Turkey
  • Ukraine
  • United Kingdom

Africa

  • Angola
  • Benin
  • Botswana
  • Burkina Faso
  • Burundi
  • Cameroon
  • Cape Verde
  • Central African Republic
  • Chad
  • Comoros
  • Congo
  • Côte d’Ivoire
  • Democratic Republic of Congo
  • Djibouti
  • Egypt
  • Equatorial Guinea
  • Eritrea
  • Eswatini (Swaziland)
  • Ethiopia
  • Gabon
  • Gambia
  • Ghana
  • Guinea
  • Guinea-Bissau
  • Kenya
  • Lesotho
  • Liberia
  • Libya
  • Madagascar
  • Malawi
  • Mali
  • Mauritania
  • Mauritius
  • Mayotte
  • Morocco
  • Mozambique
  • Namibia
  • Niger
  • Nigeria
  • Réunion
  • Rwanda
  • Saint Helena
  • São Tomé and Príncipe
  • Senegal
  • Seychelles
  • Sierra Leone
  • Somalia
  • South Africa
  • South Sudan
  • Sudan
  • Togo
  • United Republic of Tanzania (Zanzibar)
  • Tunisia
  • Uganda
  • Zambia
  • Zimbabwe

Middle East

  • Bahrain
  • Iran
  • Iraq
  • Israel and Occupied Palestinian Territories
  • Jordan
  • Kuwait
  • Lebanon
  • Oman
  • Qatar
  • Saudi Arabia
  • Syria
  • United Arab Emirates (Dubai, Abu Dhabi)
  • Yemen

Asia

  • Afghanistan
  • Kazakhstan
  • Kyrgyzstan
  • Pakistan
  • Tajikistan
  • Turkmenistan
  • Uzbekistan
  • Bangladesh
  • Bhutan
  • Brunei Darussalam
  • Cambodia
  • China
  • North Korea
  • Hong Kong
  • Laos
  • Macao
  • Malaysia (Sarawak, Sabah)
  • Maldives
  • Mongolia
  • Myanmar
  • Nepal
  • India
  • Japan
  • Philippines
  • South Korea (Korea, Republic of Korea)
  • Singapore
  • Sri Lanka
  • Taiwan
  • Thailand
  • Timor-Leste
  • Vietnam

Australasia and Pacific

  • American Samoa
  • Australia
  • Christmas Island
  • Cook Islands
  • Federated States Of Micronesia
  • Fiji
  • French Polynesia
  • Guam
  • Kiribati
  • Marshall Islands
  • Nauru
  • New Caledonia
  • New Zealand
  • Niue
  • Northern Mariana Islands
  • Palau
  • Papua New Guinea
  • Pitcairn
  • Samoa
  • Solomon Islands
  • Tokelau
  • Tonga
  • Tuvalu (Ellice Islands)
  • Vanuatu

 

Table 1 shows how the severity of symptoms of generalised tetanus can be graded.

Table 1: Severity grading of generalised tetanus
Grading of severity Signs and symptoms
Grade 1 (mild)
  • Mild-to-moderate trismus and/or general spasticity
  • Little or no dysphagia
  • No respiratory embarrassment (e.g. shallow breathing, blanching of the skin, sweating, palpitations)
Grade 2 (moderate)
  • Moderate trismus and general spasticity
  • Some dysphagia and respiratory embarrassment
  • Fleeting spasms
Grade 3a (severe)
  • Severe trismus and general spasticity
  • Severe dysphagia and respiratory difficulties
  • Severe and prolonged spasms (both spontaneous and on stimulation)
Grade 3b (very severe)
  • As for severe tetanus (Grade 3a), plus autonomic dysfunction
  • Sympathetic overdrive
Public Health England. Tetanus. Guidance on the management of suspected tetanus cases and on the assessment and management of tetanus-prone wounds. 2019. Available at: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/820628/Tetanus_information_for_health_professionals_2019.pdf (accessed April 2020)

Cause

  • Bacteria: Clostridium tetani (living in soil-faeces of animals, such as horses and cows, dust, piercing metals i.e nails and manure that enter via an open wound of any sort or cut of any sort through the skin)
  • Skin injury:
    • Piercings
    • Puncture wounds acquired in a contaminated environment (e.g. gardening injuries);
    • Splinters and other puncture wounds
    • Cuts with/without foreign objects
    • Gunshot wounds
  • Eye injuries
  • Bitten by mammal’s animal i.e. dogs, cats, bats, fox, moneys , rats and mice, pigs, guinea pigs, squirrels, horses, deer’s, meadow mole.
  • Burns with systemic (widespread) sepsis
  • Compound fractures

Treatments

  • Contaminated surgery (use of non-sterile instruments/material)
  • Injecting contaminated drugs

Illicit drugs

  • Injecting contaminated drugs
One should get a tetanus jab/shot with 48 hours of injury, if required (especially if one has not had a tetanus jab/shot for more than 10 years)

Symptoms

  • High temperature greater than 38°C (100°F) or over and/or chills and sweats longer than 72 hours?
  • Rapid heartbeat?
  • Headache which is on and off or a constant headache longer than 24 hours, High blood pressure (some have a headache or feel giddy)?
  • Aching, painful muscles, muscle cramps/spasms/stiffness, Uncontrollable muscle contractions and spasm in neck (difficulty to swallow), face and jaw?
  • Muscle stiffness in neck, face and jaw (can’t open mouth known as lock jaw) and if severe in abdomen, legs, arms and back (arched back)?
  • Muscle stiffness in chest causing breathing difficulties?

Complications /Information to beware of/General tips:

Medical Emergency Condition

Do not wait, phone for ambulance

This condition can lead to:


This condition may have similar symptoms to:


When to use Vaccine:

 Immunisation and prophylaxis recommendations for tetanus-prone wounds
  • Aged ≥11 years and received an adequateb course of tetanus vaccine and last dose within ten years
  • Aged 5–10 years and received an adequate primary course of tetanus and first booster
  • <5 years old and received an adequate primary course of tetanus
No vaccine or tetanus immunoglobulin (TIG) required No vaccine or TIG required No vaccine or TIG required Provide further doses to complete the recommended schedule (i.e. further boosters if necessary)
  • Received an adequateb course of tetanus, but last dose was >10 years ago
  • Aged 5–10 years and received an adequate primary course of tetanus but no boosters
  • Individuals born in the UK after 1961 with history of appropriate vaccination
No vaccine or TIG required Administer re-enforcing dose of vaccine Administer re-enforcing dose of vaccine

And

Immediate dose of TIG or Subgam 16% at a different site

  • Individuals who have not received an adequateb course of tetanus vaccine
  • Immunisation status unknown and/or those born before 1961
Administer re-enforcing dose of vaccine Administer re-enforcing dose of vaccine

And

Immediate dose of TIG or Subgam 16% at a different site.

Administer re-enforcing dose of vaccine

And

Immediate dose of TIG or Subgam 16% at a different site

a Clean wound is defined as less than six hours old, non-penetrating with negligible tissue damageb Adequate course is defined as receiving at least three doses of vaccinations at appropriate time intervals

Reproduced with permission from Public Health England
[3]

,
[6]

Indication First line: IM-TIG Second line: Subgam 16% (1000mg)
Table 3: Recommended dosing of intramuscular tetanus immunoglobulin (IM-TIG)/human normal immunoglobulin in tetanus-prone wounds
Most uses 250 units 1 vial (6.4mL)
More than 24 hours since the wound occurred

Heavy contamination of wound

Burns

500 units 2 vials (12.8mL)
IM-TIG: intra-muscular tetanus immunoglobulin
Public Health England. Tetanus. Guidance on the management of suspected tetanus cases and on the assessment and management of tetanus-prone wounds. 2019. Available at: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/820628/Tetanus_information_for_health_professionals_2019.pdf (accessed April 2020)

Detailed Information

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