Tourette's Syndrome and/or Tics - Medtick

Tourette’s Syndrome and/or Tics

What is it?

A neurological condition where the part of the brain that control movements (basal ganglia) is affected causing random sounds and involuntary (uncontrollable) movements of parts of the body (tics), this condition is diagnosed if symptoms occur over a period of months.

  • It usually starts at the age of seven and gets worst throughout their teenage years.
  • Boys are affected more than girls.
  • 66% will see an improvement in symptoms with no longer requiring medication.
  • 33% will have symptoms throughout their life, but symptoms become milder as one gets older.

  • Patients often report that their tics are preceded by a subjective feeling of mounting inner tension and that this is temporarily relieved by tic expression.

Crossley E & Cavanna AE. Sensory phenomena: Clinical correlates and impact on quality of life in adult patients with Tourette syndrome. Psychiatry Research 2013;209:705–710. doi: 10.1016/j.psychres.2013.04.019


Diagnosis Criteria

The DSM-5 lists four criteria for Tourette syndrome (DSM-5 code 307.23):

1. The presence of both motor and vocal/phonic tics at some time during the illness (not necessarily concurrently);

2. The persistence of tics for more than one year since first tic onset, irrespective of the duration of tic-free periods;

3. The onset age before 18 years;

4. The absence of underlying organic causes for the tics.

American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Washington, DC: American Psychiatric Association 2013.


The condition can be associated with other behavioural conditions common examples include:

  • Attention deficit hyperactivity disorder (ADHD) – short memory span and not able to stay still for long.
  • Obsessive compulsive disorder (OCD) – obsessive thoughts and behaviour (please note: this disorder is because of psychological anxiety caused by intrusive (obsessional) thoughts, whereas tics are driven by premonitory urges that are more physical in nature and are often described as sensations of somatic discomfort, pain or tension)
    • For example: in patients with Tourette syndrome there is a significantly higher prevalence of concerns for symmetry, evening-up behaviours, obsessional counting (arithmomania), ordering and “just-right” perceptions, whereas patients with pure OCD have a higher rate of concerns for contamination and cleaning/washing rituals.
  • Oppositional Defiant Disorder (ODD)-persons negative and hostile to adults and senior figures.
  • Conduct Disorder (CD)-aggression towards other and break laws.
  • Rage
  • Anxiety
  • Depression

Cause

  • Unknown
    • Dysfunction of the dopaminergic transmission within cortico-striato-cortico-frontal circuitries as a key aetiological pathway.
    • Deficit in cerebral maturation, mainly at the level of striatal interneuron migration

Felling RJ & Singer HS. Neurobiology of Tourette syndrome: Current status and need for further investigation. Journal of Neuroscience 2011;31:12387–12395. doi: 10.1523/JNEUROSCI.0150-11.2011

  • Remodelling of brain structures such as the corpus callosum

Cavanna AE, Stecco A, Rickards H et al. Corpus callosum abnormalities in Tourette syndrome: An MRI-DTI study of monozygotic twins. Journal of Neurology Neurosurgery and Psychiatry 2010;81:533–535. doi: 10.1136/jnnp.2009.173666

  • Fluctuations in tic severity may also be modulated by the activity of the autonomic nervous system *
    • Imbalance of ‘fight’ or ‘flight’
    • Surges in dopamine activity- (this hormone helps us to be happy and help with body movement)

*Nagai Y, Cavanna AE & Critchley HD. Influence of sympathetic arousal on tics: Implications for a therapeutic behavioral intervention for Tourette syndrome. Journal of Psychosomatic Research 2009;67:599–605. doi: 10.1016/j.jpsychores.2009.06.004

Syndromes

Symptoms

(Symptoms can vary from simple tics i.e. head jerking or making sounds to complex tics series of movement)

General symptoms

  • Irritated, depressed, anxiety and/or panic attacks?
  • General discomfort (muscle weakness), uneasiness or ill feeling (malaise) and/or fatigue (tiredness)?
  • Aching, painful muscles, muscle cramps/spasms/stiffness?
  • Joint stiffness and pain?
  • Headache which is on and off or a constant headache longer than 24 hours?

Examples include:

1. Body movements

Simple movement of body tic:

  • Blinking and/or rolling of eyes?
  • Grinding their teeth?
  • Jerking their head?
  • Twitching ones nose?
  • Twisting their neck?
  • Rotating their shoulders?

Complex movement of body tics:

  • Shaking of head?
  • Hitting or kicking objects?
  • Jumping?
  • Shaking?
  • Copying movement of others?
  • Making obscene and rude gestures?

2. Sounds

Simple sound tics:

  • Grunting?
  • Sore throat longer than seven days or more?
  • Clearing ones throat?
  • Have a dry cough longer than three weeks?
  • Screaming?
  • Sniffing?
  • Blowing?

Complex sound tics:

  • Repeat other person’s phrases?
  • Repeat same phrase over and over again?
  • Shout obscene and rude words?

Complications /Information to beware of/General tips:

This condition may be associated with:


Driving Authority


This condition may show similar symptoms to:

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

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