Peutz-Jehgers Syndrome - Medtick
Medtick

Peutz-Jehgers Syndrome

What is it?

Peutz-Jeghers syndrome is characterized by the development of noncancerous growths called polyps in the gastrointestinal tract (particularly the stomach and intestines) and a greatly increased risk of developing certain types of cancer.

Cause

  • Unknown in some cases
  • Family history with a gene disorder in most cases
  • Genetic disorder-Mutations in the STK11 gene (also known as LKB1).The STK11 gene is a tumor suppressor gene, which means that it normally prevents cells from growing and dividing too rapidly or in an uncontrolled way. A mutation in this gene alters the structure or function of the STK11 protein resulting uncontrolled cell growth leads to the formation of noncancerous polyps and cancerous cells.

Symptoms

  • Distinctive rash [spots of dark skin freckling (melanocytic macules)] around mouth and lips and sparingly around eyes, nose, mouth fingers, anus and soles of feet?
  • Rash on gums?
  • Anaemia?
  • Abdominal pain and/or are constant violently vomiting or vomiting longer than two days (one day if a child)?
  • Rectal bleeding?

Nail changes:

Complications /Information to beware of/General tips:

This condition can lead to:

This condition may show similar symptoms to:

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Peutz-Jehgers Syndrome in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

© Medtick - 2025. All Rights Reserved.