Parkinson's Disease - Medtick

Parkinson’s Disease

What is it?

Parkinson affects a part of the mid part of the brain (substantia nigra) that helps in muscle movement for example in walking and can occur at any age, but the chances increases as one gets older.

  • It occurs when nerve cells in the brain does not produce enough of the chemical dopamine (due to damage, death or malfunction) which helps with other chemicals to control muscle movement.
  • Symptoms occur slowly and gradually.
  • The progression of the condition can also vary to mild symptoms to points where one cannot do everyday tasks.

Cause

  • Unknown maybe due to:
  • Family history
  • Toxins
  • Pesticides

Increased Risk:

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Symptoms

(Symptoms can vary and occur in any order)

  • Slowness of movement?
  • Shaking (usually starts in hands or arms)?
  • Aching, painful muscles, muscle cramps/spasms/stiffness (including face)?
  • General discomfort (muscle weakness), uneasiness or ill feeling (malaise) and/or fatigue (tiredness)?
  • Increase thirst, heavy sweating and need to urinate frequently?
  • Passing stools difficult and constipated?
  • Low mood and depressed?
  • Pain and difficulty swallowing?
  • Low blood pressure?
  • Balance and dizziness problems?
  • Difficulty using arms, body and legs, lack of stamina and/or walking difficulties?

Advanced symptoms (Parkinson-Dementia):

  • Difficulty concentrating?
  • Difficulty with higher-order or complex thought processes?
  • Mental confusion?
  • Memory problems?
  • Difficulty understanding or performing tasks?
  • Blurred vision?
  • Headache?
  • Dry mouth?
  • Altered sense of smell?
  • Stomach pain or discomfort?
  • Intestinal gas or bloating?
  • Constipation?
  • Incontinence?
  • Nausea, dizziness, and vomiting?
  • Diarrhoea?
  • Muscle pain or discomfort?
  • Joint pain, discomfort, or swelling?
  • Tooth or jaw pain or discomfort?
  • Tingling or numbness in arms or legs?
  • Muscle weakness?
  • Fever and/or chills or sensation of cold?
  • Cold feet, hands?
  • Sleep disturbance?
  • Introvert or can’t experience pleasure?

Complications /Information to beware of/General tips:

This condition can lead to:

The following maybe be caused by infection, dehydration, constipation, electrolyte disturbances and/or Parkinson medication.


This condition can be associated with:

  • Phenylketonuria (PKU)
  • Gaucher disease – a genetic disease caused by a defect in the GBA gene which helps to produce an enzyme called glucocerebrosidase, these enzymes helps our body cells to clean up and dispose of a fatty substance in the body called glucocerebroside that the body is otherwise unable to break down. If our body cells has too much of fatty substance the cells are called ‘Gaucher cells’ and begin to build up take over normal body cells functions causing symptoms.
  • Gastroparesis
  • Dysphagia (Talking and/or swallowing difficulties)
  • Irritable bowel syndrome (IBS) without diarrohea or constipation
  • Spontaneous intracranial hypotension

Parkinson medication

Parkinson medication: This can lead to worsening of restless leg symptoms that occurs after starting a dopaminergic medication to treat restless leg (Augmentation).

  • It can take normally month to years to develop – always use the most lowest effective (dopamine agonist or long-acting dopamine agonists) dose for treatment and/or consider regular trials of dose reduction or frequent drug holidays.
  • Treatment with dopamine agonists has a well-established association with impulse control disorders, including pathological gambling, binge eating, and hypersexuality.

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This condition may show similar symptoms to:

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Parkinson’s Disease in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

  • NHS

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  • Medscape

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  • Pharmaceutical Journal

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  • Healthline

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  • Medical News Today

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  • WebMD

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  • Cleveland Clinic

    Pushing the Standards of care.

  • Mayo Clinic

    No.1 Hospital in the Nation (America)

  • Drugs.com

    Know more. Be sure.

  • National Organisation of Rare Diseases

    NORD is dedicated to supporting education, elevating care, advancing research, and driving policy for rare diseases.

  • Verywell Health

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  • Fit for Travel

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  • DR Axe

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References

  • https://www.medscape.com/viewarticle/977686?src=mkm_ret_220723_mscpmrk_parkinsons&uac=240096MZ&impID=4454851#vp_2