Melasma (Chloasma) - Medtick

Melasma (Chloasma)

What is it?

A common skin condition of adults in which light to dark brown or greyish pigmentation develops.

  • A condition of hyperpigmentation, typically symmetrical (both sides of body) and often on the face.
  • People with darker skin are generally more likely to have it.
  • The condition is benign (non- cancerous) and may resolve on its own but may be concerning to some patients due to its appearance.

There are three types:

  • Centrofacial –  involves the cheeks, chin, forehead, nose, and upper lip.
  • Malar – involves only the cheeks and nose.
  • Mandibular affects the ramus of the mandible (the part of lower jaw below the ear).

Diagnosis Tests

  • Excess melanin in patients with melasma can be visually localized to the epidermis or the dermis using a Wood lamp with a wavelength of 340-400 nm.

Cause

  • Exposure to sunlight (persons with light-brown skin types from regions of the world with intense sun exposure are much more prone to develop melasma and patients with darker Fitzpatrick skin types (FSTs) IV-VI are more likely to experience melasma than are those with fairer FST types II and III)
  • Air pollution (Polycyclic aromatic hydrocarbons and airborne particulate matter are believed to enter the skin through nanoparticles to produce reactive oxygen species that cause skin hyperpigmentation)
  • Swimming in sunlight
  • Hormonal changes
  • Family history
  • Pregnancy
  • Cosmetics:
    • Musk
    • 6-methylcoumarin

Medication

  • Hormonal:
    • Hormone replacement therapy (HRT)
    • Oral contraceptives
    • When exposed to sunlight , these medication make one more sensitive to the sun (photosensitizing).
  • Antibiotics:
  • Nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Dermatitis herpetiformis (rash associated with celiac disease and eczema complications) medication: Dapsone
  • Retinoids  (Acne) medication
  • Hypoglycaemics (diabetes) Medication: Sulfonylureas (i.e. glipizide, glyburide)
  • Neuroleptics (anticonvulsants- used in epilepsy, sleeping medication and pain relief) medication
  • Phenothiazines (i.e. chlorpromazine, fluphenazine)
  • Thioxanthenes (i.e. chlorprothixene)
  • Heart, blood pressure and diuretic medication:
    • Amiodarone
    • Diltiazem
    • Quinidine
    • Enalapril
    • Furosemide
    • Bumetanide
    • Hydrochlorothiazide
  • Cramp and/or anti-malarial medication:
    • Quinine
  • Arthritis medication:
    • Hydroxychloroquine
  • Psoriasis and severe skin condition medication:
    • 5-Fluorouracil (oral and topical)
    • Coal tar
  • Common Photosensitising Topical Agents – sunscreens:
    • Benzophenones
    • Para-aminobenzoic acid (PABA)
    • Cinnamates
    • Salicylates

Symptoms

  • Darker-than-normal skin (tan to brown skin) in darker skin (blue to black skin) affecting the cheeks, forehead, upper lip, nose and chin?
  • Darker-than-normal skin (tan to brown skin) in darker skin (blue to black skin) affecting the part of lower jaw below the ear?
  • Both sides of body or face?
  • Live in sunny climates?

Complications /Information to beware of/General tips:

General tips

  • Sun protection
  • Many cosmetics can trigger this condition (treatment should be considered by a skin specialist).

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Melasma (Chloasma) in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

  • NHS

    Find information and advice on health conditions, symptoms, healthy living, medicines and how to get help (British National Health Service).

  • Medscape

    Latest medical news and expert commentary in your specialty as well as disease information.

  • Pharmaceutical Journal

    The Pharmaceutical Journal covers analysis, features, opinion, learning and careers articles, providing insight and knowledge about drugs, pharmacy practice, medicines use and healthcare policy in the context of the pharmacy profession and pharmaceutical science.

  • Healthline

    Medical Information and health advice you can trust

  • ChatGPT

    Get instant answers, find creative inspiration, and learn something new.

  • Medical News Today

    Medical news and health news headlines posted throughout the day, every day.

  • WebMD

    Better Information. Better Health.

  • Cleveland Clinic

    Pushing the Standards of care.

  • Mayo Clinic

    No.1 Hospital in the Nation (America)

  • Drugs.com

    Know more. Be sure.

  • National Organisation of Rare Diseases

    NORD is dedicated to supporting education, elevating care, advancing research, and driving policy for rare diseases.

  • Verywell Health

    Know more. Fell better.

  • Fit for Travel

    Information on how to stay safe and healthy abroad.

  • DR Axe

    Health and fitness news. Recipes, Natural Remedies