Hyperprolactinemia - Medtick

Hyperprolactinemia

What is it?

One has higher-than-normal levels of prolactin in your blood and normally affects person under the age of 40 years old and mainly affects females (rare in males and children).

  • Prolactin (also known as lactotropin) is a hormone that’s mainly responsible for the development of mammary glands within breast tissue, milk production and lactation.
  • Prolactin levels are normally low in people assigned male at birth (AMAB) and non -lactating and non-pregnant people.
  • Prolactin levels are elevated in people who are pregnant or breastfeeding.

Normal values for prolactin

  • For people assigned male at birth: Less than 20 ng/mL (nanograms per milliliter).
  • For people assigned female at birth who are not pregnant or chestfeeding: less than 25 ng/mL.
  • For people who are pregnant or breastfeeding: 80 to 400 ng/mL.

Cause

  • Idiopathic hyperprolactinemia (no known cause)
  • Family history: multiple endocrine neoplasia (MEN) type 1
  • An overactive:
    • Pituitary gland (the main organ where prolactin is produced and is secreted)
    • Central nervous system
    • Immune system
    • Uterus
    • Mammary glands
  • Prolactinoma – Benign (noncancerous) tumour that forms in your pituitary gland and causes excess production of prolactin.
  • Large tumours (other than prolactinomas) located in or near your pituitary gland- the tumour prevents dopamine, which suppresses prolactin, from reaching your pituitary gland.
  • Hypothyroidism
  • Kidney disease
  • Shingles (especially if the rash or blisters are on your chest)
  • Chest wall injuries, such as fractured ribs, fractured sternum (breastbone) and bruising on your lungs.
  • Liver disease i.e.
    • Cirrhosis
    • Severe scarring of the liver
  • Long term kidney disease

Syndromes

Medication (dopamine helps suppress the production of prolactin in your body. Any medication that affects the production or use of dopamine in your body can make your prolactin levels rise):

Symptoms

(Some persons, have no symptoms at all)

For people assigned female at birth (AFAB), symptoms of hyperprolactinemia include:

Common symptoms:

  • Infertility problems?
  • Loss interest of sex and/or low sex drive?
  • Brittle, soft weak bones, dental problems and/or prone to fractures or curved/bone legs and/or curved spine and/or arching back?

Female:

  • Changes in menstruation not related to menopause: Irregular periods and/or less frequent and/or no period (amenorrhea)?
  • Experience dryness and itchiness in vagina and/or making sexual intercourse painful?
  • Milky discharge from your nipples when not pregnant (galactorrhea)?

For people assigned male at birth (AMAB), common symptoms of hyperprolactinemia include:

Complications /Information to beware of/General tips:

Do not wait, phone for an ambulance if have or develop:

  • Blindness
  • Haemorrhage (bleeding from any orifice)

This condition can lead to:

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Hyperprolactinemia in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

  • NHS

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  • Pharmaceutical Journal

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  • WebMD

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  • Cleveland Clinic

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  • Mayo Clinic

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  • Drugs.com

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  • National Organisation of Rare Diseases

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  • Verywell Health

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References

https://my.clevelandclinic.org/health/diseases/22284-hyperprolactinemia

https://www.healthline.com/health/hyperprolactinemia