Sephardic Jews (descendants were expelled from Spain during the 15th century)
Armenians
Turkish and Arabic people
There are many variation of this condition and one can have variations in symptoms.
This condition can have ‘flare up’ some have attacks often while others have it less often.
‘Flare up’ include: Episodic (recurrent fevers, often with pain in the abdomen, joints, or chest.
This condition can also be referred as Familial Paroxysmal Polyserositis and/or Recurrent Polyserositis.
Cause
MEFV gene mutation – almost always affects chromosome 16 (one of the 23 pairs of chromosomes that make up a person’s DNA).
Chromosome 16 is responsible for creating a protein called pyrin found in certain defensive white blood cells and helps to control inflammation- hence maybe a dysfunction in this protein.
Family history-autosomal recessive disorder (Both parents who are carriers of the recessive genes responsible and can cause a 25% chance of their sibling getting this condition)
If both parents are carriers, a child has a 25 percent chance of inheriting two recessive genes (and getting FMF), a 50 percent chance of getting one dominant and one recessive gene (and becoming a carrier), and a 25 percent chance of getting two dominant genes (and remaining unaffected).
Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice
Detailed Information
Please copy and paste any key words from the title: Familial Mediterranean Fever in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).
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