Antithrombin deficiency is a blood disorder characterized by the tendency to form clots in the veins (thrombosis).
An inherited tendency to thrombosis is known as thrombophilia. Antithrombin is a substance in the blood that limits the blood’s ability to clot (coagulation) and the primary inhibitor of thrombin, which is required for the development of blood clots.
It is also is the primary inhibitor of two clotting factors, factor Xa and factor IXa, that are required for the generation of thrombin.
An abnormally low platelet count with various causes. Low levels of platelets present risks such as bleeding and thrombosis.
Thrombocytopenia in adults is defined as a platelet count < 150,000/µL (although the correlation of bleeding risk and severity of thrombocytopenia remains uncertain)
Surgical bleeding can occur with a platelet count < 50,000/µL
Spontaneous bleeding can occur with a platelet count < 10,000/µL
Rare autosomal recessive bleeding disorder that causes a deficiency of glycoprotein Ib (GpIb), the receptor for von Willebrand factor for blood clotting (this is where von Willebrand factor attaches itself for it to function)
Very rare autoimmune disorder in which the immune system destroys the body’s red blood cells , white blood cells and/or platelets .
Affected people often experience thrombocytopenia (too few platelets) and Coombs’ positive hemolytic anemia (premature destruction of red blood cells).
An abnormality of the platelets. It is an extremely rare bleeding disorder due to a blood abnormality), in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen (needed for ones blood to clot).
Hypersplenism with secondary thrombocytopenia (50–90% of platelets are retained in the enlarged spleen resulting in a reduction of platelets in the circulating blood)
Primary immune deficiency syndrome in young children (rare, genetic disorders that impair the immune system)
For a diagnosis of drug-induced thrombocytopenia to be made with confidence, all of these criteria must be met:
The development of the low platelet count should exhibit a strict temporal relationship with the initiation of the medication
The platelet count should recover when the offending medication is discontinued
The likelihood of drug-induced thrombocytopenia should be greater than any other plausible cause
Ideally, in vitro evidence of drug-dependent antibody formation should exist
Medication:
Abciximab
Acetaminophen
Amiodarone
Ampicillin
Carbamazepine
Eptifibatide
Ethambutol
Haloperidol
Ibuprofen
Irinotecan
Naproxen
Oxaliplatin
Phenytoin
Piperacillin
Quinidine
Quinine
Ranitidine
Rifampin
Simvastatin
Tirofiban
Trimethoprim-sulfamethoxazole
Valproic acid
Vancomycin
Kava toxicity
Source: Encyclopedia Britannica
Source: CoLaz
Source: www.self.com
Source: Momtastic
Source: Medical News Today
Source: grepmed
Source: Glanzmann's thrombasthenia, Glanzmann's Research Foundation FORMATION OF A BLOOD CLOT ' Glanzmann's disease and Bernard–Soulier syndrome'
Symptoms
(Destruction of red blood cells)
General discomfort (muscle weakness), uneasiness or ill feeling (malaise) and/or fatigue (tiredness)?
Pale looking (including nails beds and gums)?
Lightheadedness?
Short of breath and/or breathing difficulties?
Rapid heartbeat?
(Destruction of white blood cells)
Runny nose, congestion, cold not cleared by over the counter medication or greater than three weeks?
Dry cough longer than three weeks?
Have initially a persistent dry cough which has now become a chesty cough with yellow/green and/or blood stained phlegm?
High temperature greater than 38°C (100°F) or over and/or chills and sweats longer than 72 hours?
Enlarged lymph node on the side of your neck or in your underarm (armpit) and/or collarbone and/or groin area and/or reoccurring mouth ulcers?
Bruises, splotchy red spots, or sores on your skin?
Mouth ulcer(s) that do not heal (mouth ulcers that have been there for three weeks or more)?
Anal or rectal sores/rectal bleeding?
Rapid heartbeat?
(Destruction of platelets and/or platelets not clotting as they should- platelets help your blood to stick together and clot in the healing process i.e. Haemophilia, Von Willebrand disease, Glanzmann’s disease)
Pain, numbness, burning and tingling (pins and needles) sensation in one’s hands and fingers (thumb and/or index finger and/or middle finger and/or ring finger and/or small finger)?
Tingling sensation in one or both legs?
Inflamed (hot, red and swollen) joints, tenderness and warmth to the touch?
Female:
Heavy menstruation?
Complications /Information to beware of/General tips:
Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice
Detailed Information
Please copy and paste any key words from the title: Blood Disorders in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).
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