Acanthosis Nigricans

What is it?

Abnormal thickening and darkening of the skin.

Skin locations include:

Face
Eyelids
Lips
Inside the mouth
Sides and back of the neck
Nipples and breasts
Navel or belly button
Elbows
Armpits
Groin
Anus
Inner thighs
Knees

Cause

Family history
Overweight/Obese
Diabetes
Insulin resistance conditions i.e.
- Insulin resistance type A
Familial partial lipodystrophy
Polycystic ovaries
Hypothyroidism
Mandibuloacral dysplasia
Stomach cancer
Liver cancer
Lymphoma cancer
People with endocrine (glandular) abnormalities
Kidney transplant patients

Syndromes

Insulin resistance conditions i.e.
- Donohue syndrome (Leprechaunism)
- Rabson-Mendenhall syndrome
Alstrom syndrome
Acrocephalopolysyndactyly disorders (Crouzon syndrome)
Bannayan-Riley-Ruvalcaba syndrome (BRRS)
Berardinelli-Seip syndrome (lack of body fat, extreme muscular appearance)
Beare-Stevenson syndrome
Cowden Syndrome
Cushing syndrome

Medication

Hormonal supplements i.e.
- HRT
- Oestrogen supplements
- Contraceptives
Corticosteroids
Niacinamide

Source: Science Direct

Source: Medikoe

Symptoms

Dark, velvety discoloration in body folds and creases?
Skin appears thickened?
Itchy skin?
Slightly smelly skin?
Skin tags may present in the area?

Complications /Information to beware of/General tips:

This condition can increase the chance of:

Diabetes Type-2

This condition may show similar symptoms to:

Ashy dermstosis of Ramirez/Erythema dyschromicumperstans/
Costello syndrome [loose skin (cutis laxa) on the neck, palms, fingers, and soles, skin may appear wrinkled and thickened, dry hardened patches of skin (hyperkeratosis) with unusually deep creases on the palms and soles]
Dermatoisiscinecienta
Multicentric osteolysis nodulosis and arthropathy spectrum
Nelson syndrome – [one to four years following the surgical removal of the adrenal glands (bilateral adrenalectomy)]
Winchester syndrome
Xeroderma Pigmentosum (De Sanctis-Cacchione syndrome)

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Acanthosis Nigricans in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

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