Where one has a low level oestrogen and/or where the ovaries stop functioning leading to lower egg production, and fertility difficulties before the age of 40 years, it used to be known as premature ovarian failure.
It differs from early menopause, which occurs in women aged between 40 and 45 years.
Diagnosis Tests
Blood tests and other presenting with menopausal symptoms
Results are : Elevated serum follicle stimulating hormone (FSH) levels (>30 IU/L) on two consecutive blood samples taken four to six weeks apart.
One may undergo tests that check your hormone levels, especially follicle stimulating hormone (FSH), which is the hormone that causes your follicles to develop and release an egg, and prolactin, the hormone that causes you to produce milk.
Anti-Müllerian hormone (AMH) levels may be checked as well to assess your egg count.
Understanding the hormonal activity in your body can help your doctor rule out other conditions.
You may also need genetic tests, especially karyotype test and tests for the FMR1 genetic difference. These tests help identify genetic conditions that can lead to POI.
The doctor may also test your bone density.
Since estrogen reduction can cause your bones to weaken, they may want to look for signs of osteoporosis.
An ultrasound may be performed to count your antral (ovarian) follicles, which contain your immature egg cells.
Heathline
Rule out other medical conditions to which it can be confused with (see below).
Cause
Unknown
Family history particularly of African-American, Hispanic and white ethnicity
Fragile X – genetic condition that causes a range of developmental problems including learning disabilities and cognitive impairment
Mutation and or defect of the gene of Follicle-stimulating hormone (FSH) receptor (FSHR)
Mutation of inhibin B – (Inhibin B is a testicular protein associated with maturation of follicles in the ovaries, it negatively regulates FSH secretion).
Unscheduled vaginal bleeding within the first three months of the regimen and is different to the regular, scheduled bleeding that occurs at the end of the progesterone phase in cyclical regimens
Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice
Detailed Information
Please copy and paste any key words from the title: Premature Ovarian Insufficiency in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).
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