Sarcoidosis - Medtick

Sarcoidosis

What is it?

Sarcoidosis or sarcoid is a disease due to a particular type of inflammation called granulomatous inflammation.

  • This is when cells involved in inflammation join or come together and form ‘lumps’ called granulomas by your immune system. Instead of first forming and then dying the granuloma heals and form scar tissue.
  • The trigger for these granulomas are unknown and probably involve the response by our own body anti-inflammatory processes.
  • It maybe similar to tuberculosis (gramulomas contain macrophages, monocytes and active T-lymphocytes ) but it is not triggered by an infection.
  • In time it can make your immune system weak and make you more prone to infection.
  • These lumps can develop at various sites in the body due to inflammation and can affect any organ of the body for example skin, heart, liver kidneys, muscles nose, sinuses , brain and nerves, more commonly in lungs, lymph glands (neck, groin and armpits), skin and eyes.
  • If lots of lumps form then it can affect the organs function and how that body part works for the body and then affect the rest of your body.
    • For example damage to the lungs can make your the right hand side of your heart to enlarge (cor-pulmonale) and damage muscles in your heart (cardiomyopathy) and lead to heart failure.
Common organs affected Chances affected with sarcoidosis
Other glands (armpit and groin) 17%
Eyes (uvetitits) 12.5%
Lung and lymph glands (chest area) 90%
Skin 25%
Nerves and nervous system 5%
Nerves and nervous system 5%
Heart 2%
Others: bones, joint, muscles, liver, spleen, kidney, gut Rare
  • Some (up to 50%) have no symptoms and are only are diagnosed with the condition when one has a chest x-ray or a skin rash for another reason.
  • It is often mis-diagnosed because other conditions can cause these symptoms.
  • Symptoms can vary because some organs are affected and/or some not at all and/or not all organs are affected at the same time.
  • The disease can develop suddenly and then disappear (if over a period of weeks it is called acute sarcoidosis), or it may appear gradually (over a period of months) and produce symptoms that come and go and can occur to continue to recur over a lifetime (chronic sarcoidosis).
    The condition often goes away by itself and more than half of cases clear up themselves in two to three years and is often mistaken for other disease.
    In other cases it can become a long-standing and serious condition where treatment is needed.
  • It is a rare condition where in the United Kingdom 3000 people are diagnosed with the condition for the first time.
  • Women tend to have it more than men, mainly in ages between 20-40 years old and seem to be more common in Scandinavian, Africa-Americans and Africa-Caribbean.

Cause

  • Unknown
  • Trigger in the environment i.e.
    • Aspirated Pneumonia
      • It is when the end of your breathing pipes the air sacks, become inflamed (hot, red, swollen) and filled with fluid.
      • This occurs when breathing something that is harmful to the body that is not infectious (bacterial, protozoan, fungal viral), but can still irritate or damage ones lungs, it could be an allergen, irritant, chemical (for example beryllium causes Berylliosis) or a foreign object which can cause pneumonia symptoms.
  • Blood vessel disorders i.e.
  • Auto-immune condition- when body reacts to a threat and the immune system attacks the organs in defence.
  • Infection (infections also cause granulomas due to response by your immune system) i.e.

Syndromes

Vitamins, herbals and minerals

Does one have two or more of the following and any of the following symptoms?

Conditions

Symptoms

(Please note symptoms do vary)

Lungs

  • Chest pain?
  • Short of breath or breathing difficulties?
  • Tight chest?
  • Wheezing?
  • Early morning ‘smokers cough’?
  • Breathing difficulties when exercising?
  • Persistent dry cough (with or without blood)?
  • Thick yellow green phlegm/brownish/blood stained phlegm (rare)?
  • Sharp pain or hurts when breathing in or out?
  • Regular and reoccurring chest infections?

Skin

  • Rash?
  • Painful red skin sores and/or bumpy rash on the arms and shin, though can occur anywhere on the body (erythema nodosum)?
  • Purple rash on face and cheeks?

Lymph areas (neck, armpits, groin)

  • Any unknown lumps or swellings on any part of body?

Neck

  • Swollen lymph glands and/or reoccurring mouth ulcers?
  • Sore throat longer than three days or more?

Eyes (Uveitis)

  • Blurred vision?
  • Flashing lights?
  • Floaters where shadows move across ones vision range?
  • Loss of vision?
  • Pain in back of eyes (common in arthritis sufferers)?
  • Pain in eyes which can get worst when one focuses on an object and/or reading?
  • Sensitive to light?
  • Severe redness in eye?

Ear

  • Sensitivity to every day noise and/or ringing noise within and/or difficulty hearing?

Heart

  • Altered heart rhythm (slow beating of heart)?
  • Heart palpitations, irregular heartbeats?
  • Cold hand and feet which can be numb and painful?

Stomach

  • Feeling discomfort, fullness, or pain on the upper left side of the abdomen; this pain may spread to your left shoulder?
  • Abdominal pain and/or are constant violently vomiting or vomiting longer than two days (one day if a child)?
  • Long term persistent indigestion, frequent heartburn or constant abdominal pain?
  • Stomach lumps?
  • Feel full quickly when eating, trapped wind and burping?
  • General discomfort, uneasiness, or ill feeling (malaise) and/or fatigue (tiredness)?
  • Unexplained weight loss?

Others

Nail changes:

Abdominal conditions (emergency)

Muscle conditions (emergency):

Detailed Information

Please copy and paste any key words from the title: Sarcoidosis in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

  • NHS

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  • WebMD

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  • Cleveland Clinic

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  • Mayo Clinic

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  • Drugs.com

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  • National Organisation of Rare Diseases

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  • Verywell Health

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  • Fit for Travel

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  • DR Axe

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