Celiac Disease - Medtick

Celiac Disease

What is it?

An autoimmune disease [involving  antibodies (IgG and IgA) not allergy based antibodies IgE)] where one’s bowel can’t tolerate the protein gluten (when digested it turns to gliadin and produces an immune inflammatory response).

  • Inflammation caused by celiac disease damages the intestinal mucosa, resulting in malabsorption, malnutrition, and maldigestion.
  • It is an adverse immune response to gluten as a result the body produces abnormal peptides (proteins).
  • These peptides trigger immune cells to produce antibodies (IgG and IgA) that cause damage to the villi (the finger-like projections in the lining of the gut.
  • Gluten is found in wheat, rye, barley, which is used to make bread, pasta, biscuits and cakes.

Diagnosis test

  • The only way to check for celiac disease and food intolerance disease is through several tests given by medical doctors , home testing kits do not always provide accurate results and should be used as a guide.
  • Testing methods include:
    • Chemiluminescence immunoassay (CLIA) from Inova Diagnostics
    • CLIA from Euroimmun
    • Fluorescence enzyme-linked immunoassay (FEIA) from Phadia
Intolerance disease and celiac disease have similar symptoms

Cause

  • Unknown
  • family history i.e. Have one or both the following genes: HLA-DQ2 and HLA-DQ8
  • Virus
  • Stressful event
  • May be an autoimmune condition:
    • Where immune system attacks its own cells. In this case cells that breaks down gluten or treats gluten as a danger to the body and doesn’t let it break down and get absorbed.
    • Maybe- gluten in your diet triggers your white blood cells to attack the tiny, finger-like projections called villi that line your small intestine that normally help you digest food  and thus one cannot absorb vitamins, minerals, and other nutrients from food.

Syndromes

Symptoms

Nail changes:

Complications /Information to beware of/General tips:

Do not wait, phone for an ambulance if have or develop:

  • Anaphylaxis
  • Intussusception
  • Necrotizing enterocolitis (babies)
  • Enteropathy-associated T-cell lymphoma (EATL)- an aggressive lymphoma of the small intestine, symptoms include:
    • Obstruction (blockage) – Severe pain and swelling of the intestine
    • Bleeding from genitals and/or anus


This condition has been associated with:

Tests

If have any of these conditions one should have a test for celiac disease:


Further digestive symptoms of celiac disease may include:


Further investigation by oneself  before visiting ones Medical Doctor:

  • What are the signs and symptoms?
  • How old is the person when first noticing the symptoms?
  • How quickly does one develop the symptoms after feeding or eating?
  • How often does symptoms start and/or are they same each time?
  • Do symptoms occur after eating /drinking particular foods and what are those foods?
  • Does one have a family history of allergy especially parents or siblings?
  • Does one suspect a particular food involved either in diet and/or breast fed mother, if so how much does one eat in order for symptoms to appear?

Allergy UK


Babies and children:

This condition can be confused with and/or may show similar symptoms to:


This condition may show similar symptoms to:

Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice

Detailed Information

Please copy and paste any key words from the title: Celiac Disease in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).

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  • Medscape

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  • Pharmaceutical Journal

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  • Healthline

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  • Medical News Today

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  • WebMD

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  • Cleveland Clinic

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  • Mayo Clinic

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  • Drugs.com

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  • National Organisation of Rare Diseases

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  • Verywell Health

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  • Fit for Travel

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  • DR Axe

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