An autoimmune disease [involving antibodies (IgG and IgA) not allergy based antibodies IgE)] where one’s bowel can’t tolerate the protein gluten (when digested it turns to gliadin and produces an immune inflammatory response).
Inflammation caused by celiac disease damages the intestinal mucosa, resulting in malabsorption, malnutrition, and maldigestion.
It is an adverse immune response to gluten as a result the body produces abnormal peptides (proteins).
These peptides trigger immune cells to produce antibodies (IgG and IgA) that cause damage to the villi (the finger-like projections in the lining of the gut.
Gluten is found in wheat, rye, barley, which is used to make bread, pasta, biscuits and cakes.
Diagnosis test
The only way to check for celiac disease and food intolerance disease is through several tests given by medical doctors , home testing kits do not always provide accurate results and should be used as a guide.
Testing methods include:
Chemiluminescence immunoassay (CLIA) from Inova Diagnostics
CLIA from Euroimmun
Fluorescence enzyme-linked immunoassay (FEIA) from Phadia
Serological tests, such as IgA-tissue transglutaminase (IgA-tTG) antibodies
Furthers Tests
Test for total IgA levels to exclude selective IgA deficiency, which affects 2% of patients with coeliac disease and can lead to false-negative results. It is also crucial to ensure that patients are on a gluten-containing diet prior to testing, as avoiding gluten can significantly affect the reliability of serology, leading to missed diagnosis. Dr Mohamed G Shiha; Professor David S Sanders Medscape
Intolerance disease and celiac disease have similar symptoms. Some persons do not show any symptoms making celiac disease difficult to diagnose, it is important that screening should be done especially in high risk groups i.e. those with other autoimmune diseases, diabetes type 1 and thyroid disease by your Medical Doctor
Cause
Unknown
family history i.e. Have one or both the following genes: HLA-DQ2 and HLA-DQ8
Virus
Stressful event
May be an autoimmune condition:
Where immune system attacks its own cells. In this case cells that breaks down gluten or treats gluten as a danger to the body and doesn’t let it break down and get absorbed.
Maybe- gluten in your diet triggers your white blood cells to attack the tiny, finger-like projections called villi that line your small intestine that normally help you digest food and thus one cannot absorb vitamins, minerals, and other nutrients from food.
Gastroesophageal reflux disease or GERD – long term Heartburn (which then can lead to: pneumonitis – asthma symptoms and /or cracking sound in lungs and/or tiredness and/or finger clubbing)
Please talk to your healthcare professional (i.e. Medical Doctor/Pharmacist) for further advice
Detailed Information
Please copy and paste any key words from the title: Celiac Disease in the following respective 'Medtick References and/or Sources' to find out more about the disease (this also may include diagnosis tests and generic medical treatments).
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