Respiratory Steroidal Inhalers Medication - Medtick

Respiratory Steroidal Inhalers Medication

What is it?

(please note that inhalers, creams, scalp applications eyes ears and nose drops and sprays rarely cause side effects since they go directly into the affected area, however if you have used it a long time or have recently started and feel poorly please see the doctor)

    • Beclomethasone (Aerobec, Becotide,Asmabec, Beclazone Easi-Breathe, Becodisk, Qvar, Clenil Modulite, Filair, Kelhale, Fostair, Trimbow, Beclovent,  Soprobec, Luforbec)
    • Budesonide (Novolizer, Pulmicort,Symbicort)
    • Ciclesonide (Alvesco)
    • Fluticasone (Flixotide, Seretide, RelvaEllipta, TrelegyEllipta, Sirdupla,Flovent,Fusacomb)
    • Mometasone (Asmanex)
    • Flunisolide (Syntaris,Aerospan,Aerobid)
    • Triamcinolone (Nasacort)

 

 

Complications /Information to beware of/General tips:

  • One can measure their respiratory condition by using a peak flow meter

Please let your medical prescriber know the following when undertaking using an inhaler:

  • How often do you use your blue inhaler (more one uses, more poor control)?
  • Do you taste your medication (press your MDI inhaler to early)?
  • Do you feel a hit at the back of your throat (inhaling in too sharply/strongly)?
  • Mouth coated in powder (not inhaling strong enough)?
  • Spacer makes a whistling noise  (inhaling too strongly)?

Inhaler Technique:

Figures 1–5 provide a summary of the techniques for the commonly used inhaler devices, and common errors with patient technique, that healthcare professionals can use as a guide before training patients.

Figure 1. How to use a metered dose inhaler (MDI)

ILLUSTRATION BY JAVIER TRIGO

1: Cap should be removed and inhaler shaken to ensure consistent delivery of dose. Device should be primed if patient is using for the first time, or if not used for a while.
2: Patient should breathe out fully.
3: Patient should breathe in slowly and steadily and press down on the inhaler device.
4: On inhalation, the patient should hold their breath for a count of ten.
5: Patient should slowly breathe out, repeat dose (if applicable), and replace mouthpiece cover. Clean device if necessary after use.

Common errors in technique made by patients:

  • Not shaking the aerosol inhaler before use
  • Not priming the aerosol inhaler before first use
  • Failing to detect an empty inhaler before use
  • Failing to breathe out fully before inhaling
  • Incorrect coordination of MDI and pMDI actuation with inspiration
  • Incorrect inspiration flow rate (breathing in too fast or too slow)
  • Failing to hold breath after inhalation

For solutions to these common errors, please see table 2.

 

Figure 2. How to use a metered dose inhaler (MDI) with spacer

ILLUSTRATION BY JAVIER TRIGO

1: Cap should be removed and the patient should check to see if the mouthpiece is clean. Inhaler should be shaken to ensure consistent delivery of dose. Device should be primed if patient is using for the first time, or if not used for a while.
2: The inhaler mouthpiece should be inserted into the end of the spacer device.
3: Patient should breathe in, and then breathe out fully.
4: The inhaler and spacer device should be held between the index finger and thumb. The spacer mouthpiece should be placed in the mouth, above the tongue. The patient should close their lips around the spacer device.
5: The patient should tilt their head back slightly toward the ceiling. The top of the inhaler device should be pressed to release a single dose of medicine. The patient should slowly breathe in all of the air and hold breath for ten seconds.
6: Patient should open mouth, remove spacer device and breathe out slowly. Patients could also use the tidal breathing technique, where they breathe slowly and steadily in and out four to five times.

Common errors in technique made by patients:

  • Not shaking the aerosol inhaler before use
  • Not priming the aerosol inhaler before first use
  • Failing to detect an empty inhaler before use
  • Failing to breathe out fully before inhaling
  • Delay in inhaling drug through a holding spacer device
  • Incorrect inspiration flow rate (breathing in too fast or too slow)
  • Failing to hold breath after inhalation
  • Poor maintenance of inhaler or spacer device

For solutions to these common errors, please see table 2.

 

Figure 3: How to use an Accuhaler

ILLUSTRATION BY JAVIER TRIGO

1: Holding the device horizontal or upright, the patient should open the inhaler by moving sliding lever in the correct direction.
2: Patient should breathe out fully but not into the Accuhaler.
3: Patient should place the inhaler device in the mouth, with the lips forming a tight seal over the mouthpiece, before breathing in quickly and deeply through the inhaler device.
4: On inhalation, the patient should hold their breath for a count of ten.
5: Patient should slowly breathe out.
6: Inhaler should be closed correctly by moving sliding lever in the correct direction. The inhaler should be cleaned as necessary.

Common errors in technique made by patients:

  • Failing to breathe out fully before inhaling
  • Incorrect positioning/holding of device
  • Not breathing in quickly and deeply at the start of inhalation
  • Failing to hold breath after inhalation
  • Poor maintenance of inhaler

For solutions to these common errors, please see table 2.

 

Figure 4: How to use a turbohaler

SOURCE: ILLUSTRATIONS BY JAVIER TRIGO

1: The patient should unscrew the cap (turning anticlockwise) and remove. Holding the inhaler upright, the dose can be loaded by turning the coloured base to the right, as far as it will go.
2: Then twist it back to the left until it clicks. It is now loaded.
3: The patient should breathe out gently, away from the device. Holding the device without covering the air inlets, the tip of the mouthpiece should be placed between the lips and a good seal made.
4: The patient should breathe in quickly and deeply and hold their breath for 5–10 seconds. Remove the device before breathing out fully. Clean the device as necessary, replace the cap and screw it shut.

Common errors in technique made by patients:

  • Incorrect positioning/holding of the device
  • Incorrect inspiration flow rate (breathing in too fast or too slow)
  • Poor maintenance of inhaler

For solutions to these common errors, please see table 2

 

Examples of common inhaler technique errors and recommendations for improvement are described in ‘Table 2: Common inhaler technique errors and suggested solutions’.

Table 2: Common inhaler technique errors and suggested solutions
Common error Explanation and suggested solutions
Not shaking an aerosol inhaler device before use Not shaking the canister properly may lead to inconsistent dosing and poorly functioning inhalers. Shake all inhalers; most dry powder inhalers (DPI) do not need shaking before use.
Not priming the aerosol inhaler device Aerosol inhalers require priming (to check that the spray is functioning) before using for the first time, or if they have not been used for a while (usually five to seven days).
Not breathing out before inhaling Breathing out fully (or as much as is comfortable) reduces the amount of air in the airways and increases the available space for air from the next breath. The result is a deeper than normal inhalation, maximising the opportunity to carry the drug to the site of action.
Incorrect positioning of inhaler device Patients should be instructed not to hold a DPI with the mouthpiece pointing downwards during, or after loading, a dose, as the drug can escape. It should be kept horizontal or upright.

The patient should keep their chin up or head slightly tilted back when using the inhaler. It should be placed correctly in the mouth and the lips should form a tight seal over the mouthpiece.

Incorrect coordination of pressured metered dose inhaler (pMDI) actuation with inspiration To deliver the medication to the lungs from a pMDI, the patient must coordinate breathing in with pressing the canister.
Delay in inhaling drug through a holding spacer device (a device when combined with a pMDI helps to improve aerosol delivery) The medication stays suspended in the spacer for a short time only, so if patients fail to take each dose without delay immediately after loading the spacer, a proportion of the dose is deposited on to the inner surface of the spacer and is therefore lost.
Incorrect inspiratory flow rate: breathing in either too fast or too slow The total lung deposition of an inhaled drug is strongly affected by the speed of inhalation.

  • Aerosol devices, such as pMDIs, require a slow and steady inhalation to increase lung deposition. When the patient inhales, the drug particles will follow the path that the air takes until a change in direction occurs, at which time the particles will try to continue to move in the same direction they were travelling. Too fast an inhalation will increase the velocity of the drug particles, thus increasing inertial impaction at the points where the airways change direction significantly (particularly at the throat and where the main airways of the lung branch out). Think about this as a sharp bend at the end of a straight piece of road: any vehicle that is travelling too fast will crash.
  • The aerosol device itself generates its own propellant and releases the particles at speed, and so a slower inhalation rate is required to guide the drug to the site of action. Furthermore, the pMDI is easy to inhale through as it has little resistance to airflow, which means it is relatively easy for patients to inhale too fast.
  • DPIs require a quick and deep inhalation to generate a large internal turbulent force to break up the formulation to optimise the particle size and lung deposition. The inhalation should, therefore, be forceful from the start and failure to achieve this high internal force increases the likelihood of the dose impacting in the mouth and throat. DPI devices have a high resistance to airflow, which limits the inhalation flow rate through the device and, consequently, patients using a DPI need to apply greater effort to generate the necessary flow for optimum drug delivery.
Not holding your breath after inhalation The ‘breath hold’ increases lung deposition through the process of sedimentation. By keeping the air still for a few seconds, a greater number of particles will sediment on to the receptor sites because of gravity.
Multiple actuations without waiting in between actuations Very rapid actuations can reduce the dose delivered per actuation.
Using an empty inhaler Patients frequently fail to detect when the inhaler is empty, particularly when using reliever aerosol devices.
Poor maintenance of inhaler or spacer device Spacers should be reviewed every 6–12 months to check that the structure is intact (e.g. no cracks), the outer casing is clean and the valve is functioning.

The Pharmaceutical Journal, PJ, July 2016, Vol 297, No 7891;297(7891):DOI:10.1211/PJ.2016.20201442

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